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Histopathological and Biochemical Evaluation of Albendazole in the Treatment of Infected Mice with Hydatid Cyst

Khadijeh Haji Mohammadi1, Mohammad Heidarpour2, Zahra Moosavi1,*, and Hassan Borji1

1Department of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran 2Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran



Introduction: Hydatidosis, caused by the larval stage of Echinococcus granulosus, is a prevalent parasitic disease affecting both humans and animals. Albendazole is currently the most effective drug for treating hydatid cysts. This research aimed to investigate the histopathological and biochemical effects of Albendazole on the liver, lung, and kidney of mice experimentally infected by hydatid cysts.Materials and methods: A total of 20 mice weighing approximately 220 g were used. The rats were randomly divided into the Albendazole group (100 mg/kg/day) and the control group (infected Rats without treatment). Atthe end of the experiment, tissue samples from the liver, lung, and kidney were collected for histopathological evaluation. Liver blood tests were used to assess liver functions or liver injury (alkaline phosphatase, alanine aminotransferase, and bilirubin).Results:After 30 days of daily treatment, the total number of cysts, size, and weight of the largest cyst were significantly lower in the Albendazole group, compared to the control group. The study addressed histopathological changes in the liver, kidneys, and lungs caused by hydatid cysts, such as tissue necrosis, hemorrhage, and local inflammation, indicating the potential for serious complications and significant damage to these organs. The group treated with Albendazole showed severe histopathological changes in the liver, kidneys, and lungs, compared to the control group. This suggests that Albendazole may trigger a more aggressive response in these organs to the cysts, leading to increased tissue damage. In addition, alkaline phosphatase, alanine aminotransferase, and bilirubin concentrations revealed a significant increase in the Albendazole group. Conclusion:While Albendazole is an effective drug for treating hydatidosis, it can also cause severe side effects on various organs in the body. Therefore, alternative treatment strategies need to be developed to minimize these adverse effects.

1. Introduction:

Hydatid cyst is one of the common parasitic diseases betweenhumans and animals, which is caused by Echinococcustapeworms1. This disease is transmitted by eating water or food containing the eggs of this parasite or through contact with an infected animal2. The eggs of this parasite are found in the feces of carnivorous animals infected with this parasite3. Dogs, foxes, and wolves are the animals that are usually infected with this parasite. These animals get sick when they eat animalparts infected with this cyst, including sheep or from the rodent family4. The type of disease in humans can vary depending on the type of cyst caused by echinococcosis. Therefore, the specific type of echinococcosis responsible for the infection determines the type of disease that occurs5. The disease is usually diagnosed through ultrasound, but a CT scan or MRI can also be used 6.

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